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Rev. Soc. Bras. Clín. Méd ; 13(2)jun. 2015. tab
Article in Portuguese | LILACS | ID: lil-749179

ABSTRACT

OBJECTIVE: Analyze bacteria involved in urinary tract nosocomial infections (UTIs), their sensitivity profile, and other correlated clinical variables. METHODS: This was a retrospective study, based on the analysis of positive urine culture reports (from100,000CFU/ml) for nosocomial infection covering the years 2009, 2010 and 2011, and on medical records. Statistical analysis was performed through SPSS 19.0 software, using chi-square tests with Yates correction and Pearson's correlation coefficient. p<0.05 was considered statistically significant. RESULTS: The sample consisted of 74 positive urine cultures, 64.9% of which from females, and 58.1% of which from patients above 50 years of age. Medical conditions accounted for 87.8% of cases, and nervous and gastrointestinal problems were the most prevalent. Hospital stay ranged from 56.7±35.7 days; 51.4% of the patients used indwelling urinary catheter, 54% of whom over a 30 day period. Klebsielle pneumoniae and Escherichia coli together accounted for 60.8% of cases. Amikacin, Gentamicin, Cefoxitin, Piperacillin-tazobactam, Imipem, Meropenem and Ertapenem showed ≥50% sensitivity. There were correlations between symptoms associated to UTI and antibiotic use after urine culture (p=0.02), and catheter use and duration of hospital stay (p=0.04). CONCLUSIONS: Female patients over 50 years of age with underlying clinical conditions originated in the nervous system or the gastrointestinal apparatus making use of indwelling urinary catheters for over 30 days and a hospital stay period of 56.7±35.7 days are more likely to develop nosocomial UTIs. Amikacin, Gentamycin and Cefoxitin are feasible options for empirical antibiotic therapy against the two most prevalent bacteria.


OBJETIVO: Analisar as bactérias envolvidas nas infecções do trato urinário (ITUs) nosocomiais, perfil de sensibilidade, e outras variáveis clínicas correlacionadas. MÉTODOS: Estudo retrospectivo, com base na análise dos laudos de urocultura positiva (a partir de 100 mil UFC/ml) para infecção nosocomial abrangendo os anos 2009, 2010 e 2011, em prontuários médicos. A análise estatística foi realizada no SPSS 19.0, utilizando os testes do qui-quadrado com correção de Yates e coeficiente de correlação de Pearson. Considerou-se estatisticamente significativo p<0,05. RESULTADOS: A amostra constitui-se de 74 uroculturas positivas, sendo 64,9% do sexo feminino, com 58,1% acima de 50 anos. As patologias clínicas corresponderam a 87,8% dos casos, sendo sistema nervoso e gastrointestinal os de maiores prevalências. Tempo de permanência hospitalar foi de 56,7±35,7 dias, 51,4% fizeram uso de SVD, sendo 54% destes com uso acima de 30 dias. As bactérias Klebsielle pneumoniae e Escherichia coli representaram juntas 60,8% dos casos. Os antibióticos Amicacina, Gentamicina, Cefoxitina, Piperaciclina-tazobactam, Imipem, Meropenem e Ertapenem apresentaram sensibilidade ≥50%. Houve correlação entre sintomas associados à ITU e uso de antibiótico após urocultura (p=0,02); tempo de uso de sonda e tempo de permanência hospitalar (p=0,04). CONCLUSÕES: Pacientes femininos com mais de 50 anos e doença de base clínica, de origem no sistema nervoso ou gastrointestinal, em uso de SVD por mais de 30 dias e tempo de permanência hospitalar de 56,7±35,7 dias, estão entre as mais propensas a desenvolverem ITU nosocomial. A Amicacina, Gentamicina e Cefoxitina apresentaram opções factíveis para a antibioticoterapia empírica as duas bactérias mais prevalentes.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Hospitals, University , Cross Infection/embryology , Cross Infection/microbiology , Urinary Tract Infections/epidemiology , Urinary Tract Infections/microbiology , Anti-Bacterial Agents/therapeutic use , Bacteria , Bacteria/isolation & purification
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